IRT Saint Exupéry pursues a series of portraits devoted to the men and women who best represent the institute: its researchers. Their high-level skills and wealth of experience contribute hugely to IRT Saint Exupéry’s performance and unique position, which is so crucial for its members and partners.
Can you tell us about your career?
Labs-on-a-chip, which were very popular at the time, held the promise of quick, precise, sensitive and low-cost biochemical analysis techniques for medical diagnosis. So I decided to get better acquainted with biotechnological engineering by joining the University of California Santa Barbara in 2008 as an associate researcher in microfluidics as part of Igor Mezić’s group, which specialised in the dynamics of complex systems. Miniaturisation raised new challenges, such as the mix between the reagent and the sample, which I tackled using electrokinetic methods consisting of applying an alternating current electric field to generate the movement of solid particles in a conductive liquid or gel. I developed micro-mixers for biochips and microplates. The biochips are micro-structured objects that are manufactured using techniques borrowed from microelectronics. A set of DNA molecules attached in rows quantifies the level of gene expression. They have multiple uses, such as determining the genetic signature of tumours in oncology or detecting pathogenic bacteria in environmental genomics. As for microplates, they can be used to perform medical diagnostics via immunoassays, which use the antigen-antibody reaction to detect and quantify antigens, antibodies or related substances.
After a year, I combined my academic work – increasing the number of inter-departmental collaborations to test the performance of micro-mixers on different types of samples (DNA, proteins and immunoassays) – with a part-time job at Integrated Fluidics Inc., a spin-off founded by Igor Mezić to design the industrialisation of the micro-mixers.
I felt the need to put down roots in Europe. The nano-engineering and systems-integration team at LAAS-CNRS in Toulouse welcomed me to do a project by the STAE foundation micro-laboratory for environmental observatories. The goal was to provide an in situ microsensor to determine the concentration and molecular form of mercury, a toxic element found in trace amounts in the water in rivers and oceans. I worked upstream of the mercury detection on preparing the sample and the filtration of suspended particles. We had to avoid conventional detection based on electric fields that could modify the molecular form of mercury, as well as the membranes, which are difficult to make and liable to get clogged up. I then developed a passive, purely hydrodynamic, technique that sorted the particles according to their size by acting on the separation of the flows. All LAAS-CNRS’ microelectronics expertise was invaluable for manufacturing the microscopic channels for this sensor.
HOW DID YOU MAKE THE TRANSITION TO THE WORLD OF AI?
WHAT IS YOUR ROLE AT IRT SAINT EXUPÉRY?
I also work as a technical supervisor on the DEEP4CAST project, which focuses on AI applied to weather forecasting (rain and cloud cover). We’ve already had good results thanks to the students and engineer who are working on it.
Last of all, I’m involved in the internal AMIMAIA project that started recently with the materials department. It aims to automatically characterise microscopic images of composite materials. I really like the dynamics of this type of project, which makes nearly as much progress around the coffee machine as it does in meetings.
What do you like at IRT Saint Exupéry?
Once again, I’m not standing still in terms of my skills, since I’m immersing myself enthusiastically in this new culture linked to AI: the primacy of conference communications rather than publishing in high-impact factor journals like Nature; the opening up of open-source code; and the reliability of the reproducibility of digital experiences that are less dependent on the vagaries of the physical world. Not to mention being in touch with the new generation of engineers that learned to read by coding. That also imposes a very dynamic rhythm, which I like a great deal.
DO YOU HAVE A SPECIAL THOUGHT YOU COULD SHARE WITH US?
 A scientific discipline that uses physical and chemical methods for archaeological studies
 BIOMImetic and Cellular Systems
 Grenoble Interdisciplinary Physics Laboratory (CNRS/Univ. Grenoble-Alpes)
 École Supérieure de Physique et Chimie Industrielles de la Ville de Paris, part of Université Paris Sciences & Lettres
 Microgravity Research Centre at the Université Libre de Bruxelles
 Littoral, environment: models and numerics (Inria Sophia-Antipolis Méditerranée/Hydrosciences Montpellier/Institut Montpelliérain Alexander Grothendieck)
 Sciences and Technologies for Aeronautics and Space
 Centre européen de recherche et de formation avancée en calcul scientifique (Airbus/Cnes/EDF/Météo-France/Onera/Safran/Total/CNRS)
 Institut de recherche en informatique de Toulouse (CNRS/UT3 Paul Sabatier/INP Toulouse/UT1 Capitole/UT2 Jean Jaurès)
 Laboratory for Analysis and Architecture of Systems